Exploring The Hormonal Route. Hair=life.

[All Might]

This is why you should never start with topical treatments to treat hairloss lmao dumbass. I never trusted topicals thats why I always use oral.

https://www.reddit.com/r/Hairloss/comments/1l4fa0v

i think using duta topically is what gave me the type 4 allergy to it

 

[sg2000]

View attachment 190424

Ok, so my DHT is crazy, but I decided just to live with it atp.
Hard to tell why it is like that, because my ACTH, 17-OHP, Cortisol, Aldosterone, Androstenedione, 3a-diol are all near low reference and DHEA-S is somehow even lower than month ago. Also, I've no clue why prolactin didn't affect anything, as well as where it came from.
Overall, I feel good, my hair doesn't fall out, skin is good, bobs are sensitive, fat is redistributed well, all even considering very high SHBG. The only downsides are more sebum on scalp (especially on forehead) and hair is kinda coarse and less soft, which makes the texture a bit weird.
DHT, tho, is definitely there, but finding out what causes it is (IMO) not worth it for me atp. I guess it's either one of CAH variations, or sort of DHT inactivation issue like 3a-HSD deficiency, or its inhibition by bile acids. I honesly blame the bile acids, because noticing some short-lived scalp inflammation from time to time when my diet is too high on fats and hair getting worse too. Regardless, even if its CAH, I have no way of treating it, because my tolerance to corticosteroids is just no bueno. Gonna just reduce my E dose a lil bit and... well, just move on with my worthless DHT mutant life.

what do you mean by high fats?which are so i can avoid it thanks

 

[BeardCombover]

Holy sh*t we're both heavy dht mutants.

Twinsies... yay =)

You also have high shbg, I rly wonder if they have something in common. My dht started to spike after my shbg increased.

Yep, they definitely have some similarities, but tbh, my SHBG was always kinda proportional to E and I actually had the same SHBG as now with 11ng/dl DHT with almost same E dose, but yours spiked for no reason if i'm not mistaken. Regarding my high SHBG btw, I think it has smth to do with high E metabolisation. There's a good chance that my E peaks with huge levels far earlier than trough and SHBG accumulates from that peaks, because of its long half life of about 2 weeks. And, again, because of high metabolism, E doesn't accumulate too well and trough levels turn out to be just tiny amounts of peak levels, if that makes sense. I think that because when I was on sublingual pills, they usually lasted for about 3-4 hours and I was getting menopausal symptoms after that. Some also say that high SHBG with moderate E = good responder, but I honestly think that there's nothing good about that, just huge fluctuations in E levels and SHBG elevation. Considering this, think I'm gonna try injecting more frequently, like 4mg/6days.

Would be good to reduce e2 anyways(to like 300 pg/ml at trough). I did that too( I hate that breast are even more sore ever since I lowered e2). Btw you have same e2 at trough as me lol.

Ye, 300pg/ml, thats actually the number I'm going for, seems like a decent amount.
Sore breasts are a very good sign IMO, mb sticking to your current dose is the answer. =)

I rly wonder if the issue is a compensation of our body against very low T. Like your free T must be very low with that shbg and total T

It definitely could be. Brain reacts to lack of hormones by stimulating one of axis organs (adrenal, thyroid, or gonads) to produce their own hormones and if deficiency doesn't resolve, some organ might become malfunction and when brain finds out about that via nerve impulses, it might start acting funny and do things like hormonal stress response via HPA. And if this stress is prolonged, and adrenal is overstimulated for a long time, might even cause CAH, afaik. Alongside with that, some pathways and co-factors might change and functionality of some other organs as a result, which will also contribute to hormonal imbalance.
Regarding my free T, honestly no idea (guess I need to measure it too), might as well be my issue, but I bet Bica does far more in terms of systemic T deprivation, than SHBG.

 

[BeardCombover]

also did you have aggressive Androgenetic Alopecia before hrt??if yes how much aggressive?

About this much.

 

[BeardCombover]

what do you mean by high fats?which are so i can avoid it thanks

Lessen animal fat and cholesterol intake, increase vegetable oils, that's it.

 

[sg2000]

About this much.

how old were you in the first pohtos?
Are the last 2 from today??

 

[sg2000]

also where is the balding gene?From mom side?

 

[BeardCombover]

Life sucks, when you have a masculine body and face being trans, you see people with changes even having bad levels, your family is dysfunctional and as if you had no family, the love of your life leaves you, society hates you and the only thing you have to escape from reality is to cry and do things to self-harm, you realize that life really is not worth it ✌planning suicide day soon, how exciting!

Had all the same problems, until I found out that "when you're beautiful and young, you just need to learn how to improvise, adapt and overcome".

 

[BeardCombover]

also where is the balding gene?From mom side?

Definitely moms.

how old were you in the first pohtos?
Are the last 2 from today??

All are from around 26 years old after I started finasteride. It was even worse before, but I've no photos of that period.

 

[sg2000]

Definitely moms.

All are from around 26 years old after I started finasteride. It was even worse before, but I've no photos of that period.

aand i mean were you started balding young like at 15 16 17? do you have a photo of 18 yrs old? btw veery impressive congrats <3

 

[BeardCombover]

aand i mean were you started balding young like at 15 16 17?

Around 20-21.

 

[sg2000]

Definitely moms.

All are from around 26 years old after I started finasteride. It was even worse before, but I've no photos of that period.

wait were the last 2 hair growth results from HRT?

 

[sg2000]

Around 20-21.

daamn in my case i started way earlier like 17 or maybe even 16

 

[BeardCombover]

tomorrow

is my injection day and im thinking about doing 0.15 ml (6 mg?).
Im dosing 0.2 ml 8 mg a week!!
however take note that i did the test the day after my next injection… but theyre high anyway

2mg is kinda a big step, I'd better reduce by 1 mg per week.

 

[BeardCombover]

wait were the last 2 hair growth results from HRT?

Nope, I was just growing out my hair while balding. =)

 

[Adri23]

Twinsies... yay =)

Yeah unfortunately it's DHT related...

Yep, they definitely have some similarities, but tbh, my SHBG was always kinda proportional to E and I actually had the same SHBG as now with 11ng/dl DHT with almost same E dose.

I think time matters too, the more time you spend with high shbg the more androgen deprived you get so the more your body try to upregulate the lack of T, but yeah it is not a proven theory either, but if you see many cancer patients the body tends to do stuff to change stuff in order to androgens to keep reaching the receptors.

but yours spiked for no reason if i'm not mistaken.

I increased bica for no reason... That might had lower my circulating T even more, then DHT started to spike and shbg started to increase. After that I had a period of big anxiety and depression and I was barely eating (lost 7 kg within 3 months) so yea SHBG increased even more from lack of calories...

Regarding my high SHBG btw, I think it has smth to do with high E metabolisation. There's a good chance that my E peaks with huge levels far earlier than trough and SHBG accumulates from that peaks, because of its long half life of about 2 weeks. And, again, because of high metabolism, E doesn't accumulate too well and trough levels turn out to be just tiny amounts of peak levels, if that makes sense. I think that because when I was on sublingual pills, they usually lasted for about 3-4 hours and I was getting menopausal symptoms after that.

Could be, that is why I think lowering e2 is important. You need to be around 300 pg/ml at trough, like trough is what really matters.

Some also say that high SHBG with moderate E = good responder, but I honestly think that there's nothing good about that, just huge fluctuations in E levels and SHBG elevation. Considering this, think I'm gonna try injecting more frequently, like 4mg/6days.

High SHBG like anything else is never good. Body needs homeostasis, if something is too low or too high it starts to give issues. Lowering your dosage is a good call!

Ye, 300pg/ml, thats actually the number I'm going for, seems like a decent amount.

Definitely. Want to go even lower when I get the orchi, like 230-250 pg/ml at trough.

Sore breasts are a very good sign IMO, mb sticking to your current dose is the answer. =)

Yeah. I always had sore nipples even with my old dosage but now it got even more intense, kinda annoying tho.

It definitely could be. Brain reacts to lack of hormones by stimulating one of axis organs (adrenal, thyroid, or gonads) to produce their own hormones and if deficiency doesn't resolve, some organ might become malfunction and when brain finds out about that via nerve impulses, it might start acting funny and do things like hormonal stress response via HPA. And if this stress is prolonged, and adrenal is overstimulated for a long time, might even cause CAH, afaik. Alongside with that, some pathways and co-factors might change and functionality of some other organs as a result, which will also contribute to hormonal imbalance.

I'm scared my body would never function like before even if I fix things...

Regarding my free T, honestly no idea (guess I need to measure it too), might as well be my issue, but I bet Bica does far more in terms of systemic T deprivation, than SHBG.

Yeah u def has to measure, and yeah bica does far more. Im not using high dosages, I am using the minimum dosage that is effective imo but if you combine that with shbg of 91.4 pmol/l the T suppression increases even more.

 

[Adri23]

Definitely moms.

Seems like when mother side is the issue we get extra fucked

 

[sg2000]

2mg is kinda a big step, I'd better reduce by 1 mg per week.

lol what?you mean 0.1 ml instead of 0.2 ml?

 

[losingbattle88]

yes i will.
I will chew gums instead lol

Or become a woman, you live in west Europe it's very easy for you.

I rather die than to become a woman. Just a little gyno would put me in deep depression.

 

[BeardCombover]

I think time matters too, the more time you spend with high shbg the more androgen deprived you get so the more your body try to upregulate the lack of T, but yeah it is not a proven theory either, but if you see many cancer patients the body tends to do stuff to change stuff in order to androgens to keep reaching the receptors.

I actually think that body can't just decide to exchange some androgen with another one, it kinda happens by itself with some complex variation of natural selection via stress response. I'm not 100% sure tho, need to do more research.

I increased bica for no reason... That might had lower my circulating T even more, then DHT started to spike and shbg started to increase. After that I had a period of big anxiety and depression and I was barely eating (lost 7 kg within 3 months) so yea SHBG increased even more from lack of calories...

Ye, all this could totally conribute to stress response, especially diet IMO.

Could be, that is why I think lowering e2 is important. You need to be around 300 pg/ml at trough, like trough is what really matters.

I mean, I just need to find the perfect day to measure my trough. And that's totally not the 7th day. =)

High SHBG like anything else is never good. Body needs homeostasis, if something is too low or too high it starts to give issues. Lowering your dosage is a good call!

Exactly!

Definitely. Want to go even lower when I get the orchi, like 230-250 pg/ml at trough.

Agreed.

Yeah. I always had sore nipples even with my old dosage but now it got even more intense, kinda annoying tho.

Annoying, but thrilling at the same time. =)

I'm scared my body would never function like before even if I fix things...

I'm sure we'll somehow find a way outa this. =)

Yeah u def has to measure, and yeah bica does far more. Im not using high dosages, I am using the minimum dosage that is effective imo but if you combine that with shbg of 91.4 pmol/l the T suppression increases even more.

Ok, I'm gonna measure next month.