SM04554 Phase 2 results

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Pavi

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Anybody catch the more adverse events in the placebo group than the two experimental groups? Lol power of the placebo effect
 
D

dfunk1130

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Tracksterderm

Tracksterderm

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dfunk1130 said:
But aren't they just doing another 3 month +45 days post discontinuation? Or did they keep patients from the pervious trial and continued another 3 months? I get that we will see biopsies but I don't see how the results could be any different with the same amount of treatment time. Correct me if I'm missing something
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https://clinicaltrials.gov/ct2/show/NCT02503137?term=Samumed&rank=3

They did a biopsy prior to and will do a biopsy after trial period.

Main differences as far as I can see is that they will get a better understanding of hair phases before and after treatment. In the first study, the primary goals were vellus/non-vellus hair count.

In the phase IIb:
Primary Outcome Measures:
Change in number of terminal hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of terminal hair follicles over the treatment period.

Change in number of anagen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of anagen hair follicles over the treatment period.

Change in number of telogen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of telogen hair follicles over the treatment period.

Change in number of catagen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of catagen hair follicles over the treatment period.

Change in number of vellus (vellus-like) miniaturized hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of vellus (vellus-like) miniaturized hair follicles over the treatment period.

Change in number of indeterminate hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of indeterminate hair follicles over the treatment period.
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dfunk1130

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Tracksterderm said:
https://clinicaltrials.gov/ct2/show/NCT02503137?term=Samumed&rank=3

They did a biopsy prior to and will do a biopsy after trial period.

Main differences as far as I can see is that they will get a better understanding of hair phases before and after treatment. In the first study, the primary goals were vellus/non-vellus hair count.

In the phase IIb:
Click to expand...
Ah well it will be interesting to see if the results are similar, worse or better, I think that if they are similar that would be interesting.
 
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Kababburger

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dfunk1130 said:
Ah well it will be interesting to see if the results are similar, worse or better, I think that if they are similar that would be interesting.
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Anyone know where to get zinc? It is supposed to be good wnt candidate

You can buy it from much sources cheaply

- - - Updated - - -


This article talks about it http://www.heflab.com/wp-content/uploads/2014/01/BBR2002.pdf
 
N

NorwoodGuardian

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Suddenly most of you guys have neglected SM while the result is not as bad as you interprete. SM has shown efficiency in as short as THREE months and you guys expect the result to be better than hair transplant in less than 12 months which is the general period length given to hair transplant, how funny it is.
 
B

Bad_Wolve

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NorwoodGuardian said:
Suddenly most of you guys have neglected SM while the result is not as bad as you interprete. SM has shown efficiency in as short as THREE months and you guys expect the result to be better than hair transplant in less than 12 months which is the general period length given to hair transplant, how funny it is.
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i was also very frustrated, but i think it was because they haven´t showen before after pics. 10 percent more in hair count is massive after 3 months, because you have also existing hair in the region which become stronger an maybe terminal. if they can give you more than 10 percent new hair after a longer period of time, it can be a game changer.
 
gagost02

gagost02

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I was wrong, just about the treatment for knee osteoarthritis.
 
A

abcdefg

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I dont see the point honestly of even releasing 3 month results. Your trying to sell the product results why not wait for the optimal time like 12 months and release them when you actually have data? A bit silly on something this big with so much money on the line
 
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